Cosmetics Europe https://validator.w3.org/feed/docs/rss2.html News and Events Consortia Permeability of 16 Straight- and Branched-Chain Parabens Using the Caco-2 Assay Suitability of the use of the intraperitoneal route in the in vivo Micronucleus Test to evaluate the genotoxicity of hair dyes Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay Our Industry A Workable EPR can only be based on correct data and the Polluter Pays Principle – Cosmetics Europe addresses recent statements by Water Operators EU policymakers tour the L’Oréal facility in Libramont, Belgium Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. III: Sensitivity of human cell types to known genotoxic agents Comparison of protocols for measuring cosmetic ingredient distribution in human and pig skin Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions ADME characterization and PBK model development of 3 highly protein-bound UV filters through topical application Case Study on the Use of Integrated Approaches for Testing and Assessment for skin sensitisation: Demonstrating the Next Generation Risk Assessment Framework using Geraniol Application of a Next Generation Risk Assessment (NGRA) framework for skin sensitisation: a case study for Diethanolamine In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: Case studies of cosmetic ingredients with low consumer exposure New framework for a non-animal approach adequately assures the safety of cosmetic ingredients – A case study on caffeine FEBEA has taken on COSMILE Europe as its main cosmetic ingredient information app Ecodesign for Sustainable Products Regulation (ESPR) Urban Wastewater Treatment Directive (UWWTD) Case Studies using the Probabilistic Aggregate Consumer Exposure Model (PACEM) for Cosmetics Ingredient Safety Assessment From worst-case to reality – Case studies illustrating tiered refinement of consumer exposure to cosmetic ingredients In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters Our team Grouping of chemicals for safety assessment: the importance of toxicokinetic properties of salicylate esters Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application Solvent solubility testing of cosmetics-relevant chemicals: methodology and correlation of water solubility to in silico predictions Challenges in working towards an internal Threshold of Toxicological Concern (iTTC) for use in the risk assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids Measurement of the Penetration of 56 Cosmetic Relevant Chemicals Into and Through Human Skin Using a Standardized Protocol Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assay to compare the in vitro hepatic and dermal metabolism of 47 cosmetics relevant chemicals Our members Comparison of the metabolism of 10 cosmetics relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants Characterization of the in vitro penetration and first-pass metabolism of genistein and daidzein using human and pig skin explants and Phenion full-thickness skin models Effect of vehicle on the in vitro penetration and metabolism of genistein and daidzein in ex vivo skin explants and the Phenion full-thickness skin model Use of a simple in vitro test to assess loss of chemical due to volatility during an in vitro human skin absorption study Vrije Universiteit Brussel training course: introduction to the environmental safety of cosmetics in the EU (16-19 September 2025) Use of in vitro ADME methods to identify suitable analogs of homosalate and octisalate for use in a read-across safety assessment Comparison of the skin penetration of three metabolically stable chemicals using fresh and frozen human skin Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion Demonstration of the first-pass metabolism in the skin of the hair dye, 4-amino-2-hydroxytoluene, using the Chip2 skin-liver microphysiological model Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum Promoting science and research Application of a skin and liver Chip2 microphysiological model to investigate the route-dependent toxicokinetics and toxicodynamics of consumer-relevant doses of genistein Suitability of different reconstructed human skin models in the skin and liver Chip2 microphysiological model to investigate the kinetics and first-pass skin metabolism of the hair dye, 4-amino-2-hydroxytoluene Cosmetics Europe Partners with Close the Glass Loop to Boost Glass Recycling Estonian Chemical Industry Association – ECIA Home